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1

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Hamby, James M., Connolly, Cleo J. C., Schroeder, Mel C., Winters, R. Thomas, Showalter, H. D. Hollis, Panek, Robert L., Major, Terry C., Olsewski, Bronislawa, Ryan, Michael J., Dahring, Tawny

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 171 KB

english, 1997

2

Synthesis and structure–activity relationships of novel substituted 8-amino, 8-thio, and 1,8-pyrazole congeners of antitubercular rifamycin S and rifampin

Yafei Jin, Sumandeep K. Gill, Paul D. Kirchhoff, Baojie Wan, Scott G. Franzblau, George A. Garcia, H.D. Hollis Showalter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 555 KB

english, 2011

3

Rifamycins – Obstacles and opportunities

Paul A. Aristoff, George A. Garcia, Paul D. Kirchhoff, H.D. Hollis Showalter

Journal:

Year:

2010

Language:

english

File:

PDF, 1.09 MB

english, 2010

4

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

Grembecka, Jolanta, He, Shihan, Shi, Aibin, Purohit, Trupta, Muntean, Andrew G, Sorenson, Roderick J, Showalter, Hollis D, Murai, Marcelo J, Belcher, Amalia M, Hartley, Thomas, Hess, Jay L, Cierpicki,

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 2.41 MB

english, 2012

5

Tyrosine Kinase Inhibitors. 14. Structure−Activity Relationships for Methyl- amino-Substituted Derivatives of 4-[(3-Bromophenyl)amino]-6-(methylamino)- pyrido[3,4- d ]pyrimidine (PD 158780), a Potent and Specific Inhibitor of the Tyrosine Kinase Activity of Receptors for the EGF Family of Growth Factors

Rewcastle, Gordon W., Murray, Donna K., Elliott, William L., Fry, David W., Howard, Curtis T., Nelson, James M., Roberts, Billy J., Vincent, Patrick W., Hollis Showalter, H. D., Winters, R. Thomas, De

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 135 KB

english, 1998

6

New generation tamoxifen analogs as potential treatments for amphetamine abuse

Carpenter, Colleen A., Altshuler, Rachel, Zestos, Alexander, Sorenson, Roderick, Jutkiewicz, Emily M., Kennedy, Robert, Showalter, Hollis, Gnegy, Margaret

Journal:

Drug and Alcohol Dependence

Year:

2017

Language:

english

File:

PDF, 54 KB

english, 2017

7

Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema

Liu, Xuwen, Wilson, Michael W., Liu, Kun, Lee, Pil, Yeomans, Larisa, Hagen, Susan E., Lin, Cheng-Mao, Wen, Bo, Sun, Duxin, White, Andrew D., Showalter, Hollis D., Antonetti, David A.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2020

File:

PDF, 1.49 MB

2020

8

ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 16. 6,5,6-Tricyclic Benzothieno[3,2-d]pyrimidines and Pyrimido[5,4-b]- and -[4,5-b]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase.

H. D. Hollis Showalter, Alexander J. Bridges, Hairong Zhou, Anthony D. Sercel, Amy McMichael, David W. Fry

Journal:

Year:

2000

Language:

english

File:

PDF, 32 KB

english, 2000

9

ChemInform Abstract: Synthesis of the Pyrano[3,2-b]pyridine Ring System under Mild Conditions.

Lalgudi S. Harikrishnan, Terri L. Boehm, H. D. Hollis Showalter

Journal:

Year:

2001

File:

PDF, 31 KB

2001

10

ChemInform Abstract: Synthesis of 3,4-Dihydro-1(2H)-isoquinolinones.

H. D. Hollis Showalter, Anthony D. Sercel, Michael A. Stier, William R. Turner

Journal:

Year:

2001

File:

PDF, 31 KB

2001

11

Synthesis and Structural—Activity Relationships of 3-Hydroxyquinazoline-2,4-dione Antibacterial Agents.

Tuan P. Tran, Edmund L. Ellsworth, Michael A. Stier, John M. Domagala, H. D. Hollis Showalter, Stephen J. Gracheck, Martin A. Shapiro, Themis E. Joannides, Rajeshwar Singh

Journal:

Year:

2004

File:

PDF, 11 KB

2004

12

ChemInform Abstract: A Novel Synthesis of N1-(Substituted)-pyrimido [5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones.

Anjanette J. Turbiak, H. D. Hollis Showalter

Journal:

Year:

2009

File:

PDF, 21 KB

2009

13

ChemInform Abstract: A New Route to Substituted Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones and Facile Extension to 5,7(6H,8H) Isomers.

Anjanette J. Turbiak, H. D. Hollis Showalter

Journal:

Year:

2010

File:

PDF, 59 KB

2010

14

ChemInform Abstract: A Novel Synthesis of 3-(Substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones.

Anjanette J. Turbiak, Jeff W. Kampf, H. D. Hollis Showalter

Journal:

Year:

2010

File:

PDF, 29 KB

2010

15

Synthesis of C-5 benzoyl and azido functionalized 2,2′-dithiobis-and 2,2′-diselenobis(1H-indoles)

Li Sun, J. Ronald Rubin, Alan J. Kraker, H. D. Hollis Showalter

Journal:

Journal of Heterocyclic Chemistry

Year:

1997

File:

PDF, 516 KB

1997

16

Synthesis of 3,4-dihydro-1(2H)-isoquinolinonesxs

H. D. Hollis Showalter, Anthony D. Sercel, Michael A. Stier, William R. Turner

Journal:

Journal of Heterocyclic Chemistry

Year:

2001

Language:

english

File:

PDF, 39 KB

english, 2001

17

A facile synthesis of substituted 3-amino-1H-quinazoline-2,4-diones

Tuan P. Tran, Edmund L. Ellsworth, Brian M. Watson, Joseph P. Sanchez, H. D. Hollis Showalter, John R. Rubin, Michael A. Stier, Judy Yip, Dai Q. Nguyen, Paul Bird, Rajeshwar Singh

Journal:

Journal of Heterocyclic Chemistry

Year:

2005

Language:

english

File:

PDF, 124 KB

english, 2005

18

The synthesis of symmetrical (2-indolyl)ethynes and reduced congeners via palladium-catalyzed couplings of 2-bromoindole precursors

Anthony D. Sercel, H. D. Hollis Showalter

Journal:

Journal of Heterocyclic Chemistry

Year:

2006

Language:

english

File:

PDF, 436 KB

english, 2006

19

Ready access to 7,8-dihydro- and 1,2,3,4-tetrahydro-1,6-naphthyridine-5(6H)-ones from simple pyridine precursors

H. D. Hollis Showalter

Journal:

Journal of Heterocyclic Chemistry

Year:

2006

Language:

english

File:

PDF, 392 KB

english, 2006

20

Synthesis of the enantiomers of the dual function 2-nitroimidazole radiation sensitizer RB 6145

Anthony D. Sercel, Vladimir G. Beylin, Mark E. Marlatt, Boguslawa Leja, H. D. Hollis Showalter, André Michel

Journal:

Journal of Heterocyclic Chemistry

Year:

2006

Language:

english

File:

PDF, 464 KB

english, 2006

21

Synthesis of [8-3H]Pentostatin

Sterling R. Putt, Jon D. Hartman, H. D. Hollis Showalter, John A. Kepler, George Taylor

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1981

Language:

english

File:

PDF, 278 KB

english, 1981

22

Synthesis of double carbon-14 labeled CI-9371 and CI-942, potential new anticancer drugs

James L. Hicks, C. C. Huang, H. D. Hollis Showalter

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1987

Language:

english

File:

PDF, 526 KB

english, 1987

23

Research into selective biomarkers of erythrocyte exposure to organophosphorus compounds

David Aminoff, Daniel A. Bochar, Amelia A. Fuller, Anna K. Mapp, H.D. Hollis Showalter, Paul D. Kirchhoff

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 691 KB

english, 2009

24

Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents

Tuan P. Tran, Edmund L. Ellsworth, Michael A. Stier, John M. Domagala, H.D. Hollis Showalter, Stephen J. Gracheck, Martin A. Shapiro, Themis E. Joannides, Rajeshwar Singh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

25

Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors

Tuan P. Tran, Edmund L. Ellsworth, Joseph P. Sanchez, Brian M. Watson, Michael A. Stier, H.D. Hollis Showalter, John M. Domagala, Martin A. Shapiro, E. Themis Joannides, Stephen J. Gracheck, Dai Q. Ng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 197 KB

english, 2007

26

Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones

Kim M. Hutchings, Tuan P. Tran, Edmund L. Ellsworth, Brian M. Watson, Joseph P. Sanchez, H.D. Hollis Showalter, Michael A. Stier, Martin Shapiro, E. Themis Joannides, Michael Huband, Dai Q. Nguyen, Sa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 174 KB

english, 2008

27

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423

Chris R. Evelyn, Jessica L. Bell, Jenny G. Ryu, Susan M. Wade, Andrew Kocab, Nicole L. Harzdorf, H.D. Hollis Showalter, Richard R. Neubig, Scott D. Larsen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.36 MB

english, 2010

28

Enediol mimics as inhibitors of the d-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis

Alejandra Yep, Roderick J. Sorenson, Michael R. Wilson, H.D. Hollis Showalter, Scott D. Larsen, Paul R. Keller, Ronald W. Woodard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 274 KB

english, 2011

29

A novel synthesis of N1-(substituted)-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones

Anjanette J. Turbiak, H.D. Hollis Showalter

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 584 KB

english, 2009

30

A novel synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones

Anjanette J. Turbiak, Jeff W. Kampf, H.D. Hollis Showalter

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 271 KB

english, 2010

31

A short, concise synthesis of queuine

Allen F. Brooks, George A. Garcia, H.D. Hollis Showalter

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 259 KB

english, 2010

32

Total syntheses of eburnamonine, quebrachamine, vincadine and epivincadine

Ernest Wenkert, Timothy D.J. Halls, Lawrence D. Kwart, Göran Magnusson, H.D.Hollis Showalter

Journal:

Year:

1981

Language:

english

File:

PDF, 892 KB

english, 1981

33

A facile synthesis of functionalized 9,10- anthracenediones via tosylate and triflate phenolic activation

H.D. Hollis Showalter, Ellen M. Berman, Judith L. Johnson, Jerry L. Atwood, William E. Hunter

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 236 KB

english, 1985

34

Studies related to the total synthesis of pentostatin: An efficient, regiospecific glycosylation of 6,7-dihydroimidazo[4,5-d][1,2]diazepin-8(3H)-one and related homologs.

H.D.Hollis Showalter, Sterling R Putt

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 235 KB

english, 1981

35

Preparation of N,N′-bis(aryl)guanidines from electron deficient amines via masked carbodiimides

Mark R. Barvian, H.D. Hollis Showalter, Annette M. Doherty

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 202 KB

english, 1997

36

Use of Enterally Delivered Angiotensin II Type Ia Receptor Antagonists to Reduce the Severity of Colitis

Manabu Okawada, Hiroyuki Koga, Scott D. Larsen, Hollis D. Showalter, Anjanette J. Turbiak, Xiaohong Jin, Peter C. Lucas, Elke Lipka, John Hillfinger, Jae Seung Kim, Daniel H. Teitelbaum

Journal:

Digestive Diseases and Sciences

Year:

2011

Language:

english

File:

PDF, 947 KB

english, 2011

37

Quaternary Diamines as Mass Spectrometry Cleavable Crosslinkers for Protein Interactions

Billy Clifford-Nunn, H. D. Hollis Showalter, Philip C. Andrews

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2012

Language:

english

File:

PDF, 736 KB

english, 2012

38

A Novel Synthesis of 2,3-Disubstituted Benzopyran-4-ones and Application to the Solid Phase

Lalgudi S Harikrishnan, H.D.Hollis Showalter

Journal:

Year:

2000

Language:

english

File:

PDF, 130 KB

english, 2000

39

Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor

Zhou, Hairong, Showalter, H. D. Hollis, Winters, R. Thomas, Smaill, Jeff B., Palmer, Brian D., Rewcastle, Gordon W., Denny, William A., McNamara, Dennis J., Dobrusin, Ellen M., Bridges, Alexander J.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 253 KB

english, 1999

40

Stereoselective Synthesis of ( S )-3-(Methylamino)-3-(( R )-pyrrolidin-3-yl)propanenitrile

Lall, Manjinder S., Hoge, Garrett, Tran, Tuan P., Kissel, William, Murphy, Sean T., Taylor, Clarke, Hutchings, Kim, Samas, Brian, Ellsworth, Edmund L., Curran, Timothy, Showalter, H. D. Hollis

Journal:

Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 445 KB

english, 2012

41

Functionalization of substituted 2-(1H)pyridones. I. A novel synthesis of a-arylgyloxylates and related systems

H. D. Hollis Showalter, Theodore H. Haskell

Journal:

Journal of Heterocyclic Chemistry

Year:

1981

Language:

english

File:

PDF, 438 KB

english, 1981

42

Functionalization of substituted 2-(1H)pyridones. II. Synthetic pathways to c-6 modified 3-cyano- and 3-carboxy-2-(1H)pyridones from a common precursor

H. D. Hollis Showalter, John M. Domagala, Joseph P. Sanchez

Journal:

Journal of Heterocyclic Chemistry

Year:

1981

Language:

english

File:

PDF, 391 KB

english, 1981

43

Studies related to the total synthesis of pentostatin. Approaches to the synthesis of (8R)-3,6,7,8-tetrahydroimidazo-[4,5-d][1,3]diazepin-8-ol and N-3 alkyl congeners

David C. Baker, Sterling R. Putt, H. D. Hollis Showalter

Journal:

Journal of Heterocyclic Chemistry

Year:

1983

File:

PDF, 478 KB

1983

44

Heteroannulated-9,10-anthracenediones. The synthesis of substituted 5- and 7-chloroanthra[1,9-cd]pyrazol-6(2H)-ones, precursors to anticancer anthrapyrazoles

H. D. Hollis Showalter, Judith L. Johnson, Jeanne M. Hoftiezer

Journal:

Journal of Heterocyclic Chemistry

Year:

1986

Language:

english

File:

PDF, 893 KB

english, 1986

45

Anticancer anilinoacridines. A process synthesis of the disubstituted amsacrine analog CI-921

Sean T. Brennan, Norman L. Colbry, Robert L. Leeds, Boguslawa Leja, Stephen R. Priebe, Michael D. Reily, H. D. Hollis Showalter, Susan E. Uhlendorf, Graham J. Atwell, William A. Denny

Journal:

Journal of Heterocyclic Chemistry

Year:

1989

File:

PDF, 510 KB

1989

46

An improved synthesis of anticancer benzothiopyranoindazoles. An efficient large-scale β-aminoethylation procedure

Vladimir G. Beylin, Norman L. Colbry, Anne B. Giordani, Om P. Goel, Donald R. Johnson, Robert L. Leeds, Boguslawa Leja, Edward P. Lewis, David M. Lustgarten, H. D. Hollis Showalter, Anthony D. Sercel,

Journal:

Journal of Heterocyclic Chemistry

Year:

1991

File:

PDF, 774 KB

1991

47

Anticancer anthrapyrazoles. The synthesis of 2-substituted 5-nitro and 5-aminoanthra[1,9-cd]pyrazol-6(2H)-ones

H. D. Hollis Showalter, William R. Turner

Journal:

Journal of Heterocyclic Chemistry

Year:

1993

File:

PDF, 306 KB

1993

48

Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity

Vaibhav Kapuria, Luke F. Peterson, H.D. Hollis Showalter, Paul D. Kirchhoff, Moshe Talpaz, Nicholas J. Donato

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 972 KB

english, 2011

49

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination

Vaibhav Kapuria, Alexander Levitzki, William G. Bornmann, David Maxwell, Waldemar Priebe, Roderick J. Sorenson, Hollis D. Showalter, Moshe Talpaz, Nicholas J. Donato

Journal:

Cellular Signalling

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

50

Biochemical and cellular effects of c-Src kinase-selective pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors

Alan J Kraker, Brian G Hartl, Aneesa M Amar, Mark R Barvian, H.D.Hollis Showalter, Charles W Moore

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 705 KB

english, 2000